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Ages Eligible for Study: 18 Years and older   (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: 18 years of age and older Life expectancy of 3 months Histological/cytological diagnosis of de novo adenocarcinoma of the pancreas Unresectable, locally advanced stage disease according to the following criteria: Head/uncinate…

Ages Eligible for Study: 18 Years and older   (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Ability to comprehend and willingness to sign a written ICF for the study. Histologically or cytologically confirmed cholangiocarcinoma that is previously untreated and considered unresectable and/or metastatic (Stage IV per the…

Ages Eligible for Study: 18 Years and older   (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion: Histologically or cytologically confirmed pancreatic adenocarcinoma of exocrine pancreas that is metastatic, unresectable, or recurrent At least one measurable lesion according to Response Evaluation Criteria in Solid Tumor V1.1 Documented disease progression…

Ages Eligible for Study: 18 Years and older  (Adult, Senior) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients must have histologically confirmed T1N1-3MO or T2-3NO-2MO esophageal or gastroesophageal junctional adenocarcinoma (Siewert I and II). Patients must have an ECOG Performance Status 0-1 Patients must be deemed a surgical candidate by…

Ages Eligible for Study: 18 Years and older  (Adult, Senior) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologic or cytologic proof of pancreatic adenocarcinoma or adenosquamous carcinoma TNM Stage: Tx-4, NO-1, MO Local radiographic reading consistent with resectable disease Measurable disease and /or non-measurable disease Registration eligibility criteria Confirmation of…

Ages Eligible for Study: 168Years and older   (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologically or cytologically confirmed Stage IV CRC that contains BRAF V600E mutation Prior systemic treatment in metastatic setting SLI: 0-1 regimens Phase 3: None Prior adjuvant or neoadjuvant therapy considered metastatic…

Ages Eligible for Study: 18 Years and older   (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Subjects must have signed an approved informed consent. Histologically confirmed diagnosis of advanced adenocarcinoma of the colon or rectum. No previous systemic chemotherapy for metastatic disease Subjects who have had prior…

Ages Eligible for Study: 18 Years and older   (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patient must have a histologic or cytologic diagnosis of pancreatic adenocarcinoma. Patients with neuroendocrine tumors, acinar cell and adenosquamous carcinomas are excluded. All disease must be assessed and documented on the…

Ages Eligible for Study: 18 Years and older  (Adult, Senior) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologically proven stage III colon adenocarcinoma (any T [Tx, T1, T2, T3, or T4], N1-2M0; includes N1C); tumors must be deemed to originate in the colon including tumors that extend into/involve the small…

Ages Eligible for Study: 18 Years and older   (Adult, Older Adult) Sexes Eligible for Study: All Sampling Method: Non-Probability Sample Criteria Inclusion Criteria: Patients over the age of 18 who have undergone surgery for stage II or III colorectal cancer Histologic diagnosis of carcinoma of the colon or rectum Undergone complete surgical resection of…