Alzheimer's Research

“Florida Alzheimer’s Disease Research Center (ADRC) Clinical Core” (Protocol #15-29-H-06)

Do you want to participate in a study which is evaluating the usefulness of brain imaging studies, tests of blood and spinal fluid, together with measurements of memory, thinking and daily functioning in the identification of Alzheimer’s disease at an early stage?

The Wien Center, in collaboration with several universities in Florida, is studying how to best use brain images, blood tests and memory evaluations to identify the earliest stages of Alzheimer’s Disease.

You may qualify for this study if you are over 60 years of age and have mild Alzheimer’s Disease or are over 70 years of age and have normal memory or mild memory loss. You will be required to have one (1)  PET scan, two   (2) MRI scans, one (1) blood draw and memory and thinking tests throughout the study. You will be reimbursed for your time.

For more information, please contact Dr. Maria Greig at (305) 674-2037, or via email at Maria.Greig-Custo@msmc.com


State of Florida Brain Bank – Searching for the Answers (Protocol #97-82-H-11)

Brain Donation is one very important way of confirming the diagnosis of Alzheimer’s disease or other forms of dementia. Brain Donation is crucial for learning more about how to diagnose and treat Alzheimer’s disease. If someone near and dear to you has been diagnosed to have Alzheimer’s disease or memory problems, the State of Florida Brain Bank can make all the arrangements to facilitate donation of the brain for confirming the diagnosis and for research. Individuals who are in the earliest stages of Alzheimer’s Disease, and those with a pre-Alzheimer condition known as Mild Cognitive Impairment are particularly important for this research. Normal brain tissue, for comparison purposes is difficult to get but is also very important for research. Individuals who are over the age of 65 and have normal memory can donate their brains for research through this program, after getting a comprehensive neurological examination and an MRI scan of the brain.

For those who participate in this study:

  • At the time of death we will arrange for the transportation and removal of the brain, at no cost.
  • We will provide a detailed pathological report, at no cost to you.

If you have any further questions or need more details about this study, please call Dr. Maria Greig or Ivon Lopez at (305) 674-2018 or via email at Maria.Greig-Custo@msmc.com or Ivon.Lopez@msmc.com. Call (305) 674-2037.


Memory Screening Studies on Healthy Aging (Protocol #01-61-H-08)

Are you worried that your memory is not what it used to be? Take advantage of a free memory screening to determine if further evaluation is needed. Participants must be at least 50 years of age. Screenings are available at:

Mount Sinai Medical Center
4302 Alton Road, #650
Miami Beach, FL 33140
Limited space · By appointment only · Please call (305) 674-2037


“A Phase 2b/3 Randomized, Double-blind, Placebo-Controlled, Parallel Group, Multicenter Study Investigating the Efficacy and Safety of JNJ-54861911 in Subjects who are Asymptomatic at Risk for Developing Alzheimer’s Dementia” (Protocol #17-05-H-01)

Do you want to participate in a study to determine whether an experimental drug, JNJ-54861911, can keep your memory and thinking from declining?

This drug targets a harmful substance in your brain, known as amyloid. Amyloid plaques are one of the hallmark features of Alzheimer’s Disease. If JNJ-54861911 stops the buildup of amyloid plaques , it may help your memory and thinking from declining with age, as occurs with Alzheimer’s Disease.

You may qualify for this study if you are between 60 and 85 years of age and have “normal” memory and thinking skills. The study drug is a pill taken every day for 4½ years. You will be required to have 3 PET scans or lumbar punctures, 6 MRI scans of your brain, multiple blood draws and electrocardiograms.  You will have memory and thinking tests throughout the study. You will be reimbursed for your time.

For more information, please call Dr. Rosemarie Rodriguez at (305) 674-2037 or via email at Rosemarie.Rodriguez@msmc.com


A Randomized, Double-Blind, Placebo-Controlled, Two-Cohort Parallel Group Study to Evaluate the Efficacy of CAD106 and CNP520 in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer’s Disease (Protocol #17-50-H-09)

Do you want to take part in a study to determine whether two experimental drugs from Novartis can keep your memory and thinking from declining, as occurs with Alzheimer’s Disease?  The Wien Center is looking for people ages 60 to 75 that have normal memory and thinking ability but may have a higher risk of developing Alzheimer’s Disease based on their genetic background.

To qualify for the study, you will first have a cheek swab to determine if your APOE genes place you at higher risk for developing Alzheimer’s Disease.  If you qualify for this study, the experimental drugs will be given either as a pill or an intramuscular injection over a period of 5 to 8 years. Some study participants will receive a placebo (like a sugar pill) instead of the experimental drugs. You will have memory and thinking tests throughout the study.  You will also be required to have several blood draws, EKGs, and MRI and PET scans of your brain over a period of 5 to 8 years. You must have a study partner (family member or friend) who can answer questions about your everyday functioning.

You will be reimbursed for your time.  For more information, please contact Dr. Maria Greig at (305) 674-2037 or at Maria.Greig-Custo@msmc.com.


Alzheimer’s Disease Neuroimaging Initiative 3 (ADNI3) (Protocol #16-53-H-09)

Do you want to participate in a study to look at the usefulness of brain scans, markers in your blood and spinal fluid, together with measurements of memory, thinking and daily functioning, in the identification of Alzheimer’s disease at an early stage?

This study is sponsored by the National Institute on Aging.  The Wien Center will be one of over 50 centers in the study.  You may qualify for this study if you are in good general health, have either good memory or memory problems, and are between 50 and 89 years of age.  If you qualify, you and a study partner will have to come to the Wien Center for up to 6 visits to test your memory and to have several different types of brain scans, including an MRI and a PET scan. Blood will be drawn from a vein in your arm and spinal fluid will be drawn from your back.  You will be reimbursed for your time.

For more information, please contact the Wien Center at (305) 674-2037 or at Maria.Greig-Custo@msmc.com


Florida consortium for African-American Alzheimer’s disease studies (FCA3DS) (Protocol #17-34-H-05)

Do you want to participate in a study to look at the genetics of Alzheimer’s Diseases among African Americans?

This study is sponsored by the Mayo Clinic in Jacksonville, Florida.  The Wien Center will be one of 3 centers from Florida in the study.  You may qualify for this study if you identify yourself as African American and  have either (1) a diagnosis of Alzheimer’s Disease or (2) good memory and are at least 65 years of age. If you qualify, you will have to come to the Wien Center for one visit to do a brief test of your memory and to have blood drawn from a vein in your arm.  You will be reimbursed for your time.

For more information, please contact Ivon Lopez at (305) 674-2018 or via email at Ivon.Lopez@msmc.com.