Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: 18 years of age and older Life expectancy of 3 months Histological/cytological diagnosis of de novo adenocarcinoma of the pancreas Unresectable, locally advanced stage disease according to the following criteria: Head/uncinate…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: HER2-positive status will be based on pretreatment biopsy material and defined as an immunohistochemistry (IHC) score of 3+ and/or positive by in situ hybridization (ISH) according to current American Society of Clinical…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients who need the fresh biopsy must also submit whole blood for ctDNA testing Patients must have pathologically proven non-small cell lung cancer (all histologic types) confirmed by tumor biopsy and/or…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Has a histologically confirmed diagnosis of Stage III or IV or recurrent Endometrial Carcinoma (EC) or carcinosarcoma (mixed Mullerian tumor) that is centrally confirmed as dMMR Has received no prior systemic…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Ability to comprehend and willingness to sign a written ICF for the study. Histologically or cytologically confirmed cholangiocarcinoma that is previously untreated and considered unresectable and/or metastatic (Stage IV per the…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Has a histologically confirmed new diagnosis of Endometrial Carcinoma or Carcinosarcoma (Mixed Mullerian Tumor) and: Has undergone curative intent surgery that included hysterectomy and bilateral salpingo-oophorectomy; and Is at high risk…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria Histologically confirmed and documented recurrent ovarian, fallopian tube, or peritoneal cancer. Only patients with high-grade serous adenocarcinoma histology are eligible. Aged 18 years or older. Eastern Cooperative Oncology Group performance status…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion: Histologically or cytologically confirmed pancreatic adenocarcinoma of exocrine pancreas that is metastatic, unresectable, or recurrent At least one measurable lesion according to Response Evaluation Criteria in Solid Tumor V1.1 Documented disease progression…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Recurrent or persistent endometrial carcinoma which has progressed or recurred after at least 1, but no more than 2, prior lines of therapy. Prior hormonal therapies (e.g., tamoxifen, aromatase inhibitors) will…
Learn MoreAges Eligible for Study: 21 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: PREREGISTRATION Patient must have biopsy-proven (consisting of >= 12 tissue cores) adenocarcinoma of the prostate with cancer present in at least one biopsy core in the most recent biopsy using initial…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients must have inflammatory breast cancer without distant metastases. All biomarker subtype groups (estrogen receptor [ER], progesterone receptor [PR], HER2) are eligible. Inflammatory disease will be defined per American Joint Committee…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Metastatic disease defined as new or progressive lesions on cross-sectional imaging or bone scan. Patients must have at least: One measurable site of disease as per Response Evaluation Criteria in Solid…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patient has signed the Informed Consent (ICF) prior to any screening procedures being performed and is able to comply with protocol requirements. Age > 18 years at time of study entry….
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Participants must have histologically confirmed HER2-negative (per 2018 American Society of Clinical Oncology [ASCO]/College of American Pathologists [CAP] joint guideline) invasive breast cancer that has metastasized to the brain. NOTE: Pathology report…
Learn MoreAges Eligible for Study: 75 Years and older (Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Participants must have histologically or cytologically confirmed diffuse large B-cell lymphoma (DLBCL), Ann Arbor stage IIX (bulky), III or IV. Participants with DLBCL transformed from follicular lymphoma (FL) or marginal zone lymphoma…
Learn MoreAges Eligible for Study: Child, Adult, Older Adult Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Participants must have been assigned to S1800D by the Southwest Oncology Group (SWOG) Statistics and Data Management Center (SDMC). Assignment to S1800D is determined by the LUNGMAP or S1400 protocol Participants must have measurable or…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Senior) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients must have histologically confirmed T1N1-3MO or T2-3NO-2MO esophageal or gastroesophageal junctional adenocarcinoma (Siewert I and II). Patients must have an ECOG Performance Status 0-1 Patients must be deemed a surgical candidate by…
Learn MoreAges Eligible for Study: 50 Years to 70 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the U.S., authorization permitting release of personal health information….
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Genders Eligible for Study: Both Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients must have undergone complete surgical resection of their stage IB (>= 4 cm), II, or IIIA NSCLC per American Joint Committee on Cancer (AJCC) 7th edition and have had negative margins;…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologically or cytologically documented Stage I to II NSCLC, with clinical Stage I/II lymph node-negative (T1 to T3N0M0) disease and planned to receive definitive treatment with SBRT. Patients may be medically…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Male Accepts Healthy Volunteers: No Criteria Inclusion Criteria: PRE-REGISTRATION Patient must have undergone a radical prostatectomy (RP) and must be registered to step 0 of this study at least 6 weeks after but not more than 16 weeks after…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Senior) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologic or cytologic proof of pancreatic adenocarcinoma or adenosquamous carcinoma TNM Stage: Tx-4, NO-1, MO Local radiographic reading consistent with resectable disease Measurable disease and /or non-measurable disease Registration eligibility criteria Confirmation of…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: All patients must have histologically confirmed newly diagnosed, previously untreated stage III or IV classical Hodgkin lymphoma (nodular sclerosing, mixed cellularity, lymphocyte-rich, or lymphocyte-depleted, or not otherwise specified [NOS]). Nodular lymphocyte…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologically confirmed invasive breast carcinoma Centrally-confirmed human epidermal growth factor receptor 2 (HER2)-positive invasive breast cancer Centrally confirmed PD-L1 and hormone receptor status Clinical stage at disease presentation: cT4/anyN/M0, any cT/N2-3/M0,…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Documented estrogen receptor (ER)-positive and HER2-negative breast tumor, as assessed locally on a primary disease specimen Participants who have multicentric (the presence of two of more tumor foci within different quadrants…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: REGISTRATION STEP 1 Participants must have pathologic (cytological or histological) proof of non-small cell lung cancer (NSCLC) Participants must have stage III NSCLC with Zubrod performance status of 2 or stage…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation. Candidacy to receive treatment with docetaxel. Exclusion Criteria: Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510). Active…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Women and men of reproductive potential should agree to use an appropriate method of birth control throughout their participation in this study due to the teratogenic potential of the therapy utilized…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients must have histologically or cytologically confirmed stage IV non-squamous non-small cell lung cancer (NSCLC) (includes M1a, M1b, and M1c stage disease, American Joint Committee on Cancer [AJCC] 8th edition). Patients…
Learn MoreAges Eligible for Study: 168Years and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologically or cytologically confirmed Stage IV CRC that contains BRAF V600E mutation Prior systemic treatment in metastatic setting SLI: 0-1 regimens Phase 3: None Prior adjuvant or neoadjuvant therapy considered metastatic…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Female Gender Based Eligibility: Yes Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Ability to comprehend and willingness to sign a written ICF for the study. Note for Germany: This excludes individuals who are housed in an institution due to…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Patients must have histologically-confirmed atypical hyperplasia (AH) or lobular carcinoma in situ (LCIS) documented by breast pathology report at any time in the past. Patients with borderline breast lesions and pleomorphic LCIS…
Learn MoreAges Eligible for Study: 18 Years and older Genders Eligible for Study: Both Accepts Healthy Volunteers: No Sampling Method: Non-Probability Sample Criteria Inclusion Criteria: Clinical stage IB (>= 4 cm), II or IIIA non-squamous non-small cell lung cancer (NSCLC) Eastern Cooperative Oncology Group (ECOG) performance status 0-1 No patients who have received neoadjuvant therapy (chemo-…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Female Gender Based Eligibility: Yes Accepts Healthy Volunteers: No Criteria Inclusion criteria Histological confirmed primary SCC of the vulva T1 tumor, not encroaching urethra/vagina/anus Depth of invasion > 1mm Tumor diameter < 4cm Unifocal tumor No enlarged (>1.5cm) or…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Previously registered to A151216 Central and/or local testing of EGFR with no EGFR exon 19 deletion or EGFR L858 R mutation Central and/or local testing of ALK with no ALK rearrangement…
Learn MoreAges Eligible for Study: 18 Years and older Genders Eligible for Study: Both Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Women of childbearing potential must have a negative serum pregnancy test within 2 weeks prior to registration; patients that are pregnant or breast feeding are excluded; a female of childbearing potential is any woman, regardless…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation Unresectable or metastatic disease Standard treatment is not available or patient declines Adequate organ function
Learn MoreAges Eligible for Study: 18 Years to 100 Years (Adult, Older Adult) Sexes Eligible for Study: Male Gender Based Eligibility: Yes Gender Eligibility Description: Male Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Provide informed consent. Be able to communicate effectively with the study personnel. Histological or cytologic proof of adenocarcinoma of the prostate not…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Subjects must have signed an approved informed consent. Histologically confirmed diagnosis of advanced adenocarcinoma of the colon or rectum. No previous systemic chemotherapy for metastatic disease Subjects who have had prior…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: STEP 1: SCREENING REGISTRATION Participants must have histologically or pathologically confirmed diagnosis of extensive stage small cell lung cancer (ES-SCLC) at the time of protocol entry Participants must have completed at…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: REGISTRATION Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 at the time of registration Patient must have histologically proven pure or mixed urothelial cancer of the…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patient must have pathologically confirmed non-squamous non-small cell lung carcinoma (NSCLC) Patient must have stage IV disease (includes M1a, M1b, or recurrent earlier stage disease), according to the 8th edition of…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Pathologically (histologically or cytologically) proven diagnosis of limited stage small cell lung cancer (Stage Tx, T1-T4, N0-3, M0, American Joint Committee on Cancer [AJCC] staging, 8th edition [Ed.]), within 60 days…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: If this will be the first patient from a registering site to receive a given RT modality (3DCRT vs. IMRT), the site must first submit pre-RT planning documents within 3 days…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Male Accepts Healthy Volunteers: No Criteria Inclusion Criteria: REGISTRATION DISEASE-RELATED CRITERIA: All patients must have a histologically or cytologically proven diagnosis of adenocarcinoma of the prostate. Patients with pure small cell carcinoma* (SCC), sarcomatoid, or squamous cell carcinoma are…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Male Accepts Healthy Volunteers: No Criteria Inclusion Criteria: REGISTRATION Patient must have had a radical prostatectomy (RP) as definitive therapy for histopathologically-proven prostatic adenocarcinoma Patient must have biochemical recurrence (BCR) after RP, with rising PSA defined as follows: If…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Male Gender Based Eligibility: Yes Gender Eligibility Description: Prostate Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Willing and able to provide written informed consent (ICF) and HIPAA authorization for the release of personal health information. A signed informed consent…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Patient must have histologically confirmed HER2-positive primary invasive breast carcinoma, determined by local testing. The tumor must…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: STEP 1 REGISTRATION Patients must have a diagnosis of hormone receptor positive (estrogen receptor positive [ER+] and/or progesterone receptor positive [PR+]), HER-2 negative, metastatic (M1) breast cancer and must be receiving or…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patient must have a histologic or cytologic diagnosis of pancreatic adenocarcinoma. Patients with neuroendocrine tumors, acinar cell and adenosquamous carcinomas are excluded. All disease must be assessed and documented on the…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patient must have a pathologically-confirmed diagnosis of non-squamous, non-small cell lung cancer (NSCLC) Patient must have advanced disease, defined as – either stage IV disease, stage IIIB disease not amenable to…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Pathologically proven diagnosis of extensive stage small cell lung cancer Partial response (PR) or stable disease (SD) after 4-6 cycles of etoposide/platinum (E/P) doublet plus atezolizumab by re-staging scans (positron emission…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Senior) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologically proven stage III colon adenocarcinoma (any T [Tx, T1, T2, T3, or T4], N1-2M0; includes N1C); tumors must be deemed to originate in the colon including tumors that extend into/involve the small…
Learn MoreAges Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Sampling Method: Non-Probability Sample Criteria Inclusion Criteria: Patients over the age of 18 who have undergone surgery for stage II or III colorectal cancer Histologic diagnosis of carcinoma of the colon or rectum Undergone complete surgical resection of…
Learn MoreAges Eligible for Study: 18 Years to 80 Years Genders Eligible for Study: Both Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients with AML, in second complete remission of AML (all FAB-subclasses), not eligible for additional intensification therapies e.g. allogeneic (allo) PSCT [independent of age]; OR Patients with relapse (smouldering) AML not eligible for additional…
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